Antidepressants: Antidepressants, other drugs and driving
From: Understanding psychiatric medications: Antidepressants - Information for consumers, families and friends (© 2009 CAMH)
Will antidepressants interact with other medications?
Antidepressants may interact with some other types of medication, even over-the-counter medications, such as cold or allergy
tablets or cough syrups, and some herbal remedies, such as St. John’s wort. Always ask your doctor, dentist or pharmacist
about potential drug interactions with the medication you are taking before you take other medications.
What if I drink alcohol or coffee while taking antidepressants?
Drinking alcohol can worsen symptoms of depression or anxiety. Alcohol can also worsen some side-effects of antidepressants,
making you more sleepy, dizzy and lightheaded. However, if you have been taking antidepressants for more than a few weeks,
and you are feeling well, having a drink or two on occasion should be okay—but remember that one drink could have the effect
of two or even three drinks.
The caffeine in coffee and other beverages can cause problems if you struggle with depression or anxiety. Depression disrupts
sleep and caffeine, a stimulant, can make the problem worse. It is better to drink decaffeinated coffee and beverages or to
decrease the amount you drink.
What if I use street drugs while taking antidepressants?
If you’re taking antidepressants, chances are you’re trying to get relief from symptoms of depression or anxiety. You want
to feel well. While street drugs such as marijuana or cocaine may have some effects that seem to make you feel better for
a while, mixing the effects of these drugs with your symptoms may make your situation worse. Street drugs may also interact
with your medication, for example, by interfering with its effectiveness or by worsening side-effects.
Will antidepressants affect my ability to drive safely?
Depression itself can lead to fatigue and concentration problems, affecting your ability to drive. Antidepressant medications
may also cause drowsiness, especially in the early stages of treatment, before your body has adjusted to the medication. If
you feel drowsy, do not drive a car or operate machinery. Alcohol, sedatives and antihistamines (cold and hay fever medication)
will worsen the problem. It’s never wise to drive after drinking alcohol, and it’s even more important to follow this rule
when taking antidepressants.

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