Inhibition in schizophrenia
Inflammation and depression
Health use patterns
Not so identical
Visual empowerment
Drug risks
Medication and memory
Stress and neurons
Virtual treatment
Mapping brain networks
Neurons and dendrites
Alcohol on the brain
Connecting for care
Parkinson’s and proteins
Personality and treatment
Driving reactions
Parenting profiles
The Toronto plot
The Toronto plot
Which genes affect weight gain after taking antipsychotic medications?
Some antipsychotic medications can lead to substantial weight gain. If a clinician could predict which patients are likely to experience this side-effect, another option could be prescribed.
This genetic plot—commonly known as a Manhattan plot—shows the connection between genetic variations and weight gain associated with antipsychotics, based on a genome-wide association study (GWAS). The chromosomes are listed across the bottom. DNA variations on chromosome 18, near the melanocortin 4 receptor (MC4R) gene, are linked to weight gain after antipsychotic use.
This particular discovery was dubbed a “Toronto plot,” and the markers are being studied in clinical trials.
Source: Dr. James Kennedy, Dr. Daniel Mueller